The influence of rhinovirus infections and SARS-CoV-2 on the release of factors related to angiogenesis and blood coagulation in the respiratory tract

Angiogenesis is a process of forming new vessels form existing ones. There are known numerous of pro-angiogenic and anti-angiogenic factors and the proportion between their expression determines the enhancement or inhibition of angiogenesis. Coagulation cascade is physiologically activated as a result of trauma or tissue disruption, but pathological prothrombotic processes are also caused by inflamma-tion. It is postulated that viral infections exert a post-thrombotic effect and may increase angiogenesis. This article summarizes reports on the influence of respiratory viruses on angiogenesis and coagulation using the example of HRV and SARS-CoV-2.